ANEclear Image - Partial - 2

ANEclear

Designed to clear inhaled anesthetics from the brain at the end of surgery.

ANEclear reverses the effects of inhaled anesthetics in the brain at the end of surgery for a safer, smoother, quicker recovery for your elderly, obese or pediatric patient.

ANEclear Image - Partial - 2

ANEclear

Designed to clear inhaled anesthetics from the brain at the end of surgery.

ANEclear reverses the effects of inhaled anesthetics in the brain at the end of surgery for a safer, smoother, quicker recovery for your elderly, obese or pediatric patient.

Overview

There are no drugs designed to bring patients out of the effects of inhaled volatile anesthetics. Tapering these anesthetics off at the end of surgery discontinues delivery, but requires clinicians and patients to wait for the effects to wear off, resulting in on-going exposure in the brain. On-going exposure contributes to delirium, postoperative cognitive dysfunction, airway complications, and nausea and vomiting.1,2

Delirium is the most common surgical complication in seniors age 65 and older.3

20-30% of seniors with surgical delirium experience cognitive dysfunction.3,4

50% of children have delirium which can lead to injury, need for restraint, drug intervention.5,6,7,8,9

NeuronMechanism of general anesthesia

Recently published research (2020) confirms that volatile anesthetics alter ion channel function in cells, which impedes electrical signaling in the neurons that control wakefulness and breathing, resulting in a loss of consciousness.10

Effect of CO2 on anesthetics and neurons

Carbon dioxide has been shown to vasodilate the cerebral vasculature, and to restore electrical signaling in neurons in the brain that control wakefulness and breathing. 11,12,13

ANEclear technology activates the brain

ANEclear’s patented process uses the patient’s own carbon dioxide to reverse the effects of inhaled volatile anesthetics in the brain, using a two-step process; 1) vasodilating the cerebral vasculature accelerating washout of anesthetics, and 2) reversing the effects these anesthetics have on neurons that control consciousness and breathing.

NeuronMechanism of general anesthesia

Recently published research (2020) confirms that volatile anesthetics alter ion channel function in cells, which impedes electrical signaling in the neurons that control wakefulness and breathing, resulting in a loss of consciousness.10

Effect of CO2 on anesthetics and neurons

Carbon dioxide has been shown to vasodilate the cerebral vasculature, and to restore electrical signaling in neurons in the brain that control wakefulness and breathing. 11,12,13

ANEclear technology activates the brain

ANEclear’s patented process uses the patient’s own carbon dioxide to reverse the effects of inhaled volatile anesthetics in the brain, using a two-step process; 1) vasodilating the cerebral vasculature accelerating washout of anesthetics, and 2) reversing the effects these anesthetics have on neurons that control consciousness and breathing.

ANEclear’s proprietary technology

Benefits

Better patient outcomes, workflow, and lower costs

Rapid reversal of volatile anesthetics from the brain following surgery reduces the effects these anesthetics have on patients during recovery, which includes delirium, respiratory complications associated with Obstructive Sleep Apnea (OSA), and Post Operative Nausea and Vomiting (PONV). These complications increase the risk of neurocognitive dysfunction, prolonged postoperative stay, unanticipated admissions, and increased costs.

ANEclear benefits

  • Accelerates washout of anesthetics from the brain
  • Returns brain function and consciousness
  • Increases spontaneous drive to breathe
  • Provides a fast, smooth anesthesia recovery
  • Lowers risk of complications
  • Increases OR / PACU performance
  • Lowers cost of patient care
  • Reduces exposure to the environment and staff
    from waste anesthetic gas
elderly patient before surgery
obese man in the hospital 500w lightened

Seniors – At risk for delirium, cognitive dysfunction, and airway complications

1 in 10 surgical patients are age 65 or older. The aging brain is more vulnerable to anesthesia. Older patients are at higher risk of the following complications.14

  • Postoperative delirium – A temporary condition that causes patients to be confused, disoriented, and experience memory problems.
  • Postoperative cognitive dysfunction (POCD) – A more serious condition that can lead to long-term memory loss making it difficult to learn, concentrate, and think.
  • Airway complications – older adults over age 65 are 2x more likely to have OSA.15

Obese – At risk for airway complications associated with Obstructive Sleep Apnea

According to the CDC 39.8% of U.S. adults are obese. These individuals are at increased risk of OSA and adverse airway events following surgery.

  • Incidence of OSA in Surgery – Studies estimate that 24–41% of elective surgery patients are at risk for OSA.17
  • OSA related airway risks – Risks associated with OSA and anesthesia include upper-airway obstruction, difficult tracheal intubation, postoperative respiratory depression, and airway obstruction.18

For older patients, ANEclear restores brain function, breathing, and consciousness to quickly return these patients to baseline for a safer recovery.

For obese patients, ANEclear restores wakefulness and breathing to increase the spontaneous drive to breathe and protect airway reflexes during recovery.

elderly patient before surgery

Seniors – At risk for delirium, cognitive dysfunction, and airway complications

1 in 10 surgical patients are age 65 or older. The aging brain is more vulnerable to anesthesia. Older patients are at higher risk of the following complications.14

  • Postoperative delirium – A temporary condition that causes patients to be confused, disoriented, and experience memory problems.
  • Postoperative cognitive dysfunction (POCD) – A more serious condition that can lead to long-term memory loss making it difficult to learn, concentrate, and think.
  • Airway complications – older adults over age 65 are 2x more likely to have OSA.15

For older patients, ANEclear restores brain function, breathing, and consciousness to quickly return these patients to baseline for a safer recovery.

obese man in the hospital 500w lightened

Obese – At risk for airway complications associated with Obstructive Sleep Apnea

According to the CDC 39.8% of U.S. adults are obese. These individuals are at increased risk of OSA and adverse airway events following surgery.

  • Incidence of OSA in Surgery – Studies estimate that 24–41% of elective surgery patients are at risk for OSA.16
  • OSA related airway risks – Risks associated with OSA and anesthesia include upper-airway obstruction, difficult tracheal intubation, postoperative respiratory depression, and airway obstruction.17

For obese patients, ANEclear restores wakefulness and breathing to increase the spontaneous drive to breathe and protect airway reflexes during recovery.

Resources

ANEclear eLearning Module

For quick reference, following are the five subsections contained in the eLearning Module:

device in use 500w

Technical Briefs

Research and Publications

Frequently Asked Questions

      1. Munk L, et al. Post-anaesthetic emergence delirium in adults: incidence, predictors and consequences. Acta Anaesthesiol Scand 2016;60:1059-1066.
      2. Frost E, et al. Differential diagnosis of delayed awakening from general anesthesia. Middle East J Anaesthesiol 2014;22.
      3. American Society of Anesthesiologists Brain Health Initiative website Nov 2020. Available from: www.asahq.org/brainhealthinitiative.
      4. Inouye S. Delirium in Older Persons N Engl J Med 2006;354(11):1157–1165.
      5. Cole JW, et al. Emergence behaviour in children: defining the incidence of excitement and agitation following anaesthesia. Paediatr Anaesth 2002;12:442–7.
      6. Voepel-Lewis T, et al. A prospective cohort study of emergence agitation in the pediatric postanesthesia care unit. Anesth Analg 2003;96:1625–30.
      7. Stamper M, et al. Identifying pediatric emergence delirium by using the PAED scale: A quality improvement project. AORN Journal 2014:99(4):480-494.
      8. Lepouse C, et al. Emergence delirium in adults in the post-anaesthesia care unit. Br J Anaesth 2006 Jun;96(6):747-53.
      9. Sikich N, et al. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology 2004 May;100(5):1138-45.
      10. Pavel, M, et al. Studies on the mechanism of general anesthesia. Proc Natl Acad Sci Jun 2020;117(24):13757-13766.
      11. Ito H, et al. Changes in human cerebral blood flow and cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography. J Cereb Blood Flow Metab. 2003;23:665–70.
      12. Sandoz G, et al. Extracellular Acidification Exerts Opposite Actions on TREK1 and TREK2 Potassium Channels via a Single Conserved Histidine Residue. Proc Natl Acad Sci 2009;106(34):14628–14633.
      13. Williams R, et al. Control of hypothalamic orexin neurons by acid and CO2. Proc Natl Acad Sci 2007;104:10685–10690.
      14. American Society of Anesthesiologists Surgery Risks Age website Nov 2020. Available from: www.asahq.org/madeforthismoment/preparing-for-surgery/risks/age.
      15. Bixler E, et al. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 1998;157:144–148.
      16. Chung F, et al. Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea. Anesth Analg 2016;123:452–73.
      17. Vasu T, et al. Obstructive sleep apnea syndrome and perioperative complications: a systematic review of the literature. J Clin Sleep Med 2012;8(2):199-207.

Frequently Asked Questions

  1. Munk L, et al. Post-anaesthetic emergence delirium in adults: incidence, predictors and consequences. Acta Anaesthesiol Scand 2016;60:1059-1066.
  2. Frost E, et al. Differential diagnosis of delayed awakening from general anesthesia. Middle East J Anaesthesiol 2014;22.
  3. American Society of Anesthesiologists Brain Health Initiative website Nov 2020. Available from: www.asahq.org/brainhealthinitiative.
  4. Inouye S. Delirium in Older Persons N Engl J Med 2006;354(11):1157–1165.
  5. Cole JW, et al. Emergence behaviour in children: defining the incidence of excitement and agitation following anaesthesia. Paediatr Anaesth 2002;12:442–7.
  6. Voepel-Lewis T, et al. A prospective cohort study of emergence agitation in the pediatric postanesthesia care unit. Anesth Analg 2003;96:1625–30.
  7. Stamper M, et al. Identifying pediatric emergence delirium by using the PAED scale: A quality improvement project. AORN Journal 2014:99(4):480-494.
  8. Lepouse C, et al. Emergence delirium in adults in the post-anaesthesia care unit. Br J Anaesth 2006 Jun;96(6):747-53.
  9. Sikich N, et al. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology 2004 May;100(5):1138-45.
  10. Pavel, M, et al. Studies on the mechanism of general anesthesia. Proc Natl Acad Sci Jun 2020;117(24):13757 – 13766.
  11. Ito H, et al. Changes in human cerebral blood flow and cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography. J Cereb Blood Flow Metab. 2003;23:665–70.
  12. Sandoz G, et al. Extracellular Acidification Exerts Opposite Actions on TREK1 and TREK2 Potassium Channels via a Single Conserved Histidine Residue. Proc Natl Acad Sci 2009;106(34):14628 – 14633.
  13. Williams R, et al. Control of hypothalamic orexin neurons by acid and CO2. Proc Natl Acad Sci 2007;104:10685 – 10690.
  14. American Society of Anesthesiologists Surgery Risks Age website Nov 2020. Available from: www.asahq.org/madeforthismoment/preparing-for-surgery/risks/age.
  15. Bixler E, et al. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 1998;157:144–148.
  16. Chung F, et al. Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea. Anesth Analg 2016;123:452–73.
  17. Vasu T, et al. Obstructive sleep apnea syndrome and perioperative complications: a systematic review of the literature. J Clin Sleep Med 2012;8(2):199-207.